Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | CFB | P00751 | 7/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018857 | 0.92 | MAPT (0.44) | MAPTATRCA12CA1CA2 | |
| SCHEMBL11021741 | 0.89 | ATR (0.44) | MAPTATRPKN1PKN2CHEK2 | |
| SCHEMBL11021898 | 0.89 | ATR (0.53) | ATRPKN1PKN2CFBCHEK2 | |
| SCHEMBL11020318 | 0.88 | CA12 (0.54) | ATRPKN1PKN2CFBCHEK2 | |
| SCHEMBL11021561 | 0.88 | L3MBTL1 (0.47) | MAPTATRPKN1PKN2CFB | |
| SCHEMBL11018186 | 0.87 | CYP3A4 (0.48) | ATRPKN1PKN2CFB | |
| SCHEMBL11016115 | 0.86 | CFB (0.47) | MAPTATRPKN1PKN2CFB | |
| SCHEMBL11018077 | 0.84 | CYP2C9 (0.54) | ATRPKN1PKN2CFBCHEK2 | |
| SCHEMBL11017639 | 0.82 | MAPT (0.49) | MAPTATRPKN1PKN2CFB | |
| SCHEMBL11017899 | 0.82 | CHEK2 (0.50) | MAPTCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |