Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ATR | Q13535 | 1/20 | 0.46 |
| ▸ | ACR | P10323 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019640 | 0.93 | MAPT (0.47) | MAPTATRACRL3MBTL1POLB | |
| SCHEMBL11018196 | 0.84 | CHEK2 (0.51) | MAPTL3MBTL1CHEK2PDE4APDE4B | |
| SCHEMBL11018668 | 0.81 | KDM4E (0.48) | MAPTATRL3MBTL1NPC1TP53 | |
| SCHEMBL11020867 | 0.78 | TP53 (0.51) | MAPTATRL3MBTL1POLBNPC1 | |
| SCHEMBL11018192 | 0.77 | MAPT (0.48) | MAPTL3MBTL1TP53RAB9ATDP1 | |
| SCHEMBL11018781 | 0.77 | ATR (0.52) | ATRL3MBTL1F2F10PLG | |
| SCHEMBL11018042 | 0.76 | CHEK2 (0.48) | MAPTL3MBTL1POLBNPC1TP53 | |
| SCHEMBL11021561 | 0.76 | L3MBTL1 (0.47) | MAPTATRACRL3MBTL1PKN1 | |
| SCHEMBL11017978 | 0.76 | ALDH1A1 (0.49) | MAPTATRL3MBTL1NPC1RAB9A | |
| SCHEMBL11018637 | 0.73 | ALDH1A1 (0.44) | MAPTATRL3MBTL1POLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |