Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.47 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11020391 | 0.92 | AMY1A (0.60) | AMY1ANPBWR1MEN1NPC1RAB9A | |
| SCHEMBL11021215 | 0.91 | AMY1A (0.45) | AMY1ANPBWR1MEN1NPC1RAB9A | |
| SCHEMBL11021228 | 0.84 | AMY1A (0.54) | AMY1ANPBWR1MEN1NPC1RAB9A | |
| SCHEMBL11018830 | 0.83 | PDE2A (0.44) | AMY1AMEN1NPC1RAB9AKMT2A | |
| SCHEMBL11019245 | 0.82 | CHEK2 (0.44) | NPC1RAB9AMAPTPDE2APDGFRB | |
| SCHEMBL11018202 | 0.81 | PDE2A (0.43) | AMY1AGAAPDE2ACHEK2 | |
| SCHEMBL11036642 | 0.81 | PDE2A (0.41) | AMY1APDE2ACHEK2 | |
| SCHEMBL11018765 | 0.81 | SCD (0.41) | NPC1RAB9ALMNANFKB1HTT | |
| SCHEMBL11020236 | 0.81 | CHEK2 (0.48) | PDE2ACHEK2 | |
| SCHEMBL11020057 | 0.79 | CHEK2 (0.46) | PDE2ACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |