Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11018211 | 0.92 | CHEK2 (0.47) | PDE2ATOP1TOP2ACHEK2AMY1A | |
| SCHEMBL11018823 | 0.91 | TOP1 (0.40) | TOP1TOP2AMAOBMAOACYP1A1 | |
| SCHEMBL11018830 | 0.85 | PDE2A (0.44) | PDE2ATOP1TOP2AMAOBMAOA | |
| SCHEMBL11018831 | 0.83 | TOP1 (0.46) | TOP1TOP2AMAOBCHEK2 | |
| SCHEMBL11019245 | 0.82 | CHEK2 (0.44) | PDE2ACHEK2 | |
| SCHEMBL9634540 | 0.81 | PDE5A (0.47) | PDE2ATOP1TOP2AMAOBMAOA | |
| SCHEMBL11018765 | 0.81 | SCD (0.41) | PDE2AMAOBMAOACHEK2 | |
| SCHEMBL11036642 | 0.81 | PDE2A (0.41) | PDE2ATOP1TOP2ACHEK2AMY1A | |
| SCHEMBL11020236 | 0.81 | CHEK2 (0.48) | PDE2ACHEK2PARP1 | |
| SCHEMBL11020385 | 0.81 | AMY1A (0.50) | PDE2ACHEK2AMY1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | claimed |
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |