Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | TTK | P33981 | 3/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021091 | 0.92 | ATR (0.48) | CA12CA1CA2CA9TTK | |
| SCHEMBL11022213 | 0.91 | ATR (0.44) | TRPV4ATRPDE5AGUSBBRPF1 | |
| SCHEMBL11020313 | 0.89 | CA2 (0.54) | CA12CA1CA2CA9ATR | |
| SCHEMBL11021236 | 0.88 | KDM4E (0.42) | TRPV4KMT2AATRPDE5ABRPF1 | |
| SCHEMBL11021736 | 0.88 | MAPT (0.43) | TRPV4KMT2AATRPDE5AGUSB | |
| SCHEMBL11022217 | 0.83 | ATR (0.53) | TRPV4ATRCHEK2MAPTSCD | |
| SCHEMBL10763275 | 0.82 | MAPK10 (0.42) | CA12CA1CA2CA9PDE5A | |
| SCHEMBL11018065 | 0.81 | PDE5A (0.37) | TRPV4KMT2APDE5AGUSBCHEK2 | |
| SCHEMBL11020318 | 0.81 | CA12 (0.54) | CA12CA1CA2CA9ATR | |
| SCHEMBL11021670 | 0.81 | PDE5A (0.38) | TRPV4KMT2APDE5AGUSBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |