Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 5/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11022217 | 0.92 | ATR (0.53) | ATRTRPV4CYP11B1CYP11B2NPBWR1 | |
| SCHEMBL11021081 | 0.91 | CA12 (0.43) | ATRTRPV4PDE5ASCDGUSB | |
| SCHEMBL11021236 | 0.89 | KDM4E (0.42) | ATRTRPV4PDE5ABRPF1MAPT | |
| SCHEMBL11021736 | 0.89 | MAPT (0.43) | ATRTRPV4PDE5AGUSBBRPF1 | |
| SCHEMBL11021893 | 0.89 | ATR (0.44) | ATRCYP11B1CYP11B2SLC6A9PDE5A | |
| SCHEMBL11021091 | 0.83 | ATR (0.48) | ATRTRPV4SCDMAPT | |
| SCHEMBL10763275 | 0.82 | MAPK10 (0.42) | PDE5ASCD | |
| SCHEMBL10765448 | 0.82 | ATR (0.44) | ATRCYP11B1CYP11B2SLC6A9NPBWR1 | |
| SCHEMBL11018065 | 0.82 | PDE5A (0.37) | TRPV4PDE5AGUSBMAPT | |
| SCHEMBL11021670 | 0.81 | PDE5A (0.38) | TRPV4PDE5AGUSBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |