Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.43 |
| ▸ | ACACA | Q13085 | 5/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 12/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11028523 | 0.82 | ACACB (0.39) | ACACBACACADPP4BACE1SLC6A4 | |
| SCHEMBL2070159 | 0.82 | ACACB (0.39) | ACACBACACADPP4BACE1SLC6A4 | |
| SCHEMBL2072081 | 0.78 | BACE1 (0.37) | ACACBACACABACE1 | |
| SCHEMBL1941357 | 0.77 | ACACB (0.48) | ACACBACACADPP4BACE1APP | |
| SCHEMBL1941359 | 0.77 | ACACB (0.48) | ACACBACACADPP4BACE1APP | |
| SCHEMBL1344157 | 0.77 | ACACB (0.39) | ACACBACACADPP4BACE1SLC6A4 | |
| SCHEMBL1942867 | 0.76 | ACACB (0.50) | ACACBACACADPP4BACE1SLC6A4 | |
| SCHEMBL2525634 | 0.76 | ACACB (0.37) | ACACBACACADPP4BACE1SLC6A4 | |
| SCHEMBL8905942 | 0.76 | GAA (0.42) | DPP4 | |
| SCHEMBL1942308 | 0.76 | ACACB (0.45) | ACACBACACABACE1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106905215-B | Process for preparing 1-H-pyrrolidine-2, 4-dione derivatives | 拜耳知识产权有限责任公司 | 2021-10-01 | — | — | CN | disclosed |
| EP-3372580-B1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2020-07-22 | — | — | EP | disclosed |
| EP-3372580-A1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2018-09-12 | — | — | EP | disclosed |
| EP-2668158-B1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | BAYER IP GMBH (DE) | 2018-06-27 | — | — | EP | disclosed |
| US-8859782-B2 | Process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| EP-2668158-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | Bayer Intellectual Property GmbH (DE) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101047-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2012-08-02 | — | — | WO | disclosed |
| US-20120190865-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190865-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | DHPS, HPD, DOHH | ACACB 4094/4885ACACA 4346/4885DPP4 912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.