Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.39 |
| ▸ | ACACA | Q13085 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2525634 | 0.81 | ACACB (0.37) | ACACBACACASLC6A4SLC6A3DPP4 | |
| SCHEMBL2886584 | 0.78 | ACACB (0.33) | ACACBACACADPP4BACE1 | |
| SCHEMBL1943774 | 0.78 | BACE1 (0.37) | ACACBACACADPP4BACE1 | |
| SCHEMBL5429034 | 0.78 | DPP4 (0.37) | ACACBACACASLC6A4SLC6A3DPP4 | |
| SCHEMBL16562510 | 0.77 | ACACB (0.34) | ACACBACACASLC6A4SLC6A3DPP4 | |
| SCHEMBL11025895 | 0.77 | ACACB (0.43) | ACACBACACASLC6A4SLC6A3DPP4 | |
| SCHEMBL2759733 | 0.77 | ALDH1A1 (0.31) | — | |
| SCHEMBL13366888 | 0.77 | MAPT (0.33) | — | |
| SCHEMBL3076232 | 0.76 | ACACB (0.32) | ACACBACACASLC6A4SLC6A3DPP4 | |
| SCHEMBL11028523 | 0.75 | ACACB (0.39) | ACACBACACASLC6A4SLC6A3DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030969-B1 | Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones | BAYER IP GMBH (DE) | 2015-03-18 | — | — | EP | disclosed |
| US-8063096-B2 | Spirocyclic 3-phenyl-3substituted-4-ketolactams and-lactones | BAYER CROPSCIENCE AG (DE) | 2011-11-22 | — | — | US | disclosed |
| EP-1432680-B1 | SPIROCYCLIC 3-PHENYL-3-SUBSTITUTED 4-KETOLACTAMS AND 4-KETOLACTONES | BAYER CROPSCIENCE AG (DE) | 2009-04-15 | — | — | EP | disclosed |
| EP-2030969-A1 | Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones | Bayer CropScience AG (DE) | 2009-03-04 | — | — | EP | disclosed |
| US-20080274893-A1 | Spirocyclic 3-Phenyl-3substituted-4-Ketolactams and-lactones | FISCHER REINER | 2008-11-06 | — | — | US | disclosed |
| US-7425575-B2 | Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones | BAYER CROPSCIENCE AG (DE) | 2008-09-16 | — | — | US | disclosed |
| US-20050032885-A1 | Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones | BAYER CROPSCIENCE AG (DE) | 2005-02-10 | — | — | US | disclosed |
| EP-1432680-A1 | SPIROCYCLIC 3-PHENYL-3-SUBSTITUTED 4-KETOLACTAMS AND 4-KETOLACTONES | Bayer CropScience AG (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003029213-A9 | SPIROCYCLIC 3-PHENYL-3-SUBSTITUTED 4-KETOLACTAMS AND 4-KETOLACTONES | BAYER CROPSCIENCE AG (DE) | 2003-11-13 | — | — | WO | disclosed |
| WO-2003029213-A1 | SPIROCYCLIC 3-PHENYL-3-SUBSTITUTED 4-KETOLACTAMS AND 4-KETOLACTONES | BAYER CROPSCIENCE AG (DE) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080274893-A1 | Spirocyclic 3-Phenyl-3substituted-4-Ketolactams and-lactones | PDHX, PGLS, PKLR | ACACB 753/4885ACACA 737/4885SLC6A4 4376/4885 |
| US-20050032885-A1 | Spirocyclic 3-phenyl-3-substituted 4-ketolactams and 4-ketolactones | PDHX, CYP2A6, CYP2D6 | ACACB 854/4885ACACA 795/4885SLC6A4 3512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.