Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL397297 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL395658 | 0.77 | TSHR (0.33) | CYP1A2CA1CA2LMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL394711 | 0.76 | CA2 (0.32) | ALDH1A1CA2 | |
| Bromide SCHEMBL6312692 | 0.73 | CA2 (0.32) | ALDH1A1CA2 | |
| Fluoride Ion SCHEMBL6304345 | 0.73 | CA2 (0.32) | ALDH1A1CA2 | |
| Iodide SCHEMBL6307196 | 0.73 | CA2 (0.32) | ALDH1A1CA2 | |
| Hydrochloric Acid SCHEMBL395656 | 0.73 | CA4 (0.37) | CA4 | |
| Hydrochloric Acid SCHEMBL6304295 | 0.72 | ALDH1A1 (0.37) | MEN1KMT2AALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL4360215 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL6306103 | 0.70 | CA1 (0.40) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062134-B2 | Half-metallocene compounds and catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140243491-A1 | Half-Metallocene Compounds and Catalyst Compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-08-28 | — | — | US | disclosed |
| US-8759246-B2 | Half-metallocene compounds and catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-06-24 | — | — | US | disclosed |
| US-20130085060-A1 | Half-Metallocene Compounds and Catalyst Compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2013-04-04 | — | — | US | disclosed |
| US-8309748-B2 | Half-metallocene compounds and catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-11-13 | — | — | US | disclosed |
| US-20120190803-A1 | HALF-METALLOCENE COMPOUNDS AND CATALYST COMPOSITIONS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190803-A1 | HALF-METALLOCENE COMPOUNDS AND CATALYST COMPOSITIONS | POLM, AP2M1, GSTM2 | SMN1; SMN2 2604/4885MEN1 698/4885KMT2A 777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.