Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11024284 | 0.85 | LMNA (0.41) | MAOAALDH1A1PGRMAOBNR3C1 | |
| SCHEMBL11025101 | 0.81 | KMT2A (0.44) | ALDH1A1 | |
| SCHEMBL6211155 | 0.74 | PGR (0.43) | BRD4NOTUMBACE1PGR | |
| SCHEMBL812654 | 0.71 | PGR (0.50) | PGR | |
| SCHEMBL6211150 | 0.70 | PGR (0.52) | PGR | |
| SCHEMBL11030508 | 0.68 | DDB1 (0.44) | ALDH1A1BACE1 | |
| SCHEMBL8187313 | 0.68 | MAPT (0.59) | ALDH1A1 | |
| SCHEMBL6631173 | 0.68 | ATM (0.38) | ALDH1A1 | |
| SCHEMBL812655 | 0.68 | CNR2 (0.35) | NOTUMALDH1A1PGRNR3C1AR | |
| SCHEMBL19238939 | 0.67 | HTR2A (0.39) | BRD4MAOAALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106905215-B | Process for preparing 1-H-pyrrolidine-2, 4-dione derivatives | 拜耳知识产权有限责任公司 | 2021-10-01 | — | — | CN | disclosed |
| EP-3372580-B1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2020-07-22 | — | — | EP | disclosed |
| EP-3372580-A1 | METHOD FOR THE PREPARATION OF 1-H-PYRROLIDIN-2,4-DIONE-DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2018-09-12 | — | — | EP | disclosed |
| EP-2668158-B1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | BAYER IP GMBH (DE) | 2018-06-27 | — | — | EP | disclosed |
| US-9272997-B2 | Process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20140371468-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2014-12-18 | — | — | US | disclosed |
| US-8859782-B2 | Process for the preparation of 1-H-pyrrolidine-2,4-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2014-10-14 | — | — | US | disclosed |
| EP-2668158-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | Bayer Intellectual Property GmbH (DE) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101047-A1 | METHOD FOR PRODUCING 1-H-PYRROLIDINE-2,4-DIONE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2012-08-02 | — | — | WO | disclosed |
| US-20120190865-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190865-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | DHPS, HPD, DOHH | BRD4 825/4885MAOA 745/4885NOTUM 3096/4885 |
| US-20140371468-A1 | Process for the Preparation of 1-H-pyrrolidine-2,4-dione Derivatives | DHPS, HPD, DOHH | BRD4 825/4885MAOA 745/4885NOTUM 3096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.