Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1908101 | 0.86 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL2053235 | 0.78 | AKR1B1 (0.37) | ALOX15AKR1B1 | |
| SCHEMBL2049103 | 0.77 | GPR84 (0.39) | ALOX15 | |
| SCHEMBL4259041 | 0.77 | GPR84 (0.39) | ALOX15 | |
| SCHEMBL10937554 | 0.77 | GPR84 (0.39) | ALOX15 | |
| SCHEMBL5899762 | 0.74 | ARG1 (0.34) | SLC6A2SLC6A4 | |
| SCHEMBL11214435 | 0.71 | ALOX5 (0.40) | AKR1B1 | |
| SCHEMBL4253394 | 0.71 | AKR1B1 (0.31) | KDM4EAKR1B1 | |
| SCHEMBL5899581 | 0.69 | GRM2 (0.33) | — | |
| SCHEMBL14714718 | 0.69 | TERT (0.49) | SLC6A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068998-B1 | (Z)-1-ARYL-2-AMINOMETHYL-CYCLOPROPANE-CARBOXYLATES, THEIR PREPARATION AND THEIR USE AS MEDICINES IN THE TREATMENT OF VARIOUS DISORDERS | PIERRE FABRE S.A. (FR) | 1985-08-28 | — | — | EP | claimed |
| EP-0068998-B1 | (Z)-1-ARYL-2-AMINOMETHYL-CYCLOPROPANE-CARBOXYLATES, THEIR PREPARATION AND THEIR USE AS MEDICINES IN THE TREATMENT OF VARIOUS DISORDERS | PIERRE FABRE S.A. (FR) | 1985-08-28 | — | — | EP | disclosed |
| EP-0068998-A1 | (Z)-1-aryl-2-aminomethyl-cyclopropane-carboxylates, their preparation and their use as medicines in the treatment of various disorders | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | disclosed |