Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | PLD2 | O14939 | 6/20 | 0.52 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11032153 | 0.85 | HSD11B1 (0.64) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| Hydrochloric Acid SCHEMBL11033163 | 0.84 | HSD11B1 (0.62) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| SCHEMBL11033997 | 0.83 | PLD1 (0.53) | OPRM1OPRK1OPRL1PLD2BCHE | |
| SCHEMBL5777516 | 0.82 | PLD2 (0.68) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| SCHEMBL11430686 | 0.81 | PLD2 (0.61) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| SCHEMBL11268724 | 0.81 | OPRK1 (0.58) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| SCHEMBL11033245 | 0.81 | PLD2 (0.71) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| Hydrochloric Acid SCHEMBL11032713 | 0.81 | ADRA1A (0.63) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| Bromide SCHEMBL11034926 | 0.80 | OPRK1 (0.57) | OPRM1OPRK1OPRL1CHRM1DRD2 | |
| Hydrochloric Acid SCHEMBL11327865 | 0.80 | ADRB2 (0.57) | OPRM1OPRK1OPRL1CHRM1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-B1 | NOVEL PIPERIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1982-06-30 | — | — | EP | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |