Guanosine

Guanosine

SCHEMBL11034252

N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.66

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HINT1 P49773 10/20 0.66
ADORA2A P29274 3/20 0.58
ADORA2B P29275 3/20 0.58
ADORA3 P0DMS8 3/20 0.58
ADORA1 P30542 3/20 0.58
GSK3A P49840 2/20 0.53
RPS6KA3 P51812 2/20 0.53
MAPK14 Q16539 2/20 0.53
HPGD P15428 1/20 0.51
TAAR1 Q96RJ0 1/20 0.51
NT5E P21589 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E626 SCHEMBL5365314 0.90 HINT1 (0.66) HINT1GSK3ARPS6KA3MAPK14NT5E
E626 SCHEMBL15670781 0.90 HINT1 (0.66) HINT1GSK3ARPS6KA3MAPK14NT5E
Adenosine SCHEMBL225271 0.86 INMT (0.61) ADORA2AADORA2BADORA3ADORA1
Adenosine SCHEMBL225269 0.86 INMT (0.61) ADORA2AADORA2BADORA3ADORA1
Adenosine SCHEMBL28133223 0.85 INMT (0.63) ADORA2AADORA2BADORA3ADORA1
E626 SCHEMBL15670356 0.85 HINT1 (0.60) HINT1GSK3ARPS6KA3MAPK14NT5E
Inosine SCHEMBL8836252 0.84 ADORA2A (0.55) ADORA2AADORA2BADORA3ADORA1HPGD
Guanosine SCHEMBL14060669 0.82 HPGD (0.57) HINT1ADORA2AADORA2BADORA3GSK3A
Guanosine SCHEMBL27904526 0.82 HPGD (0.73) HINT1ADORA2AADORA2BADORA3GSK3A
Cytidine SCHEMBL28132451 0.81 LMNA (0.61) ADORA2AADORA2BADORA3ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59190966-A None JP disclosed
JP-S59190966-A TRYPTOPHAN-GUANOSINE MOLECULAR COMPOUND AND PRODUCTION THEREOF AJINOMOTO CO INC 1984-10-29 JP disclosed