Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.73 |
| ▸ | RHOA | P61586 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822800 | 0.85 | HSD11B1 (1.00) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL2345581 | 0.85 | HSD11B1 (1.00) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL10954111 | 0.82 | HSD11B1 (0.81) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL10508168 | 0.82 | HSD11B1 (0.77) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL10964170 | 0.81 | HSD11B1 (0.75) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL10958289 | 0.81 | HSD11B1 (0.75) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL10954905 | 0.81 | HSD11B1 (0.77) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL6796426 | 0.80 | HSD11B1 (0.73) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL30218271 | 0.80 | HSD11B1 (0.73) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 | |
| SCHEMBL3419653 | 0.80 | HSD11B1 (0.68) | HSD11B1KDM4EUSP2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4551525-A | Process for preparing N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide | KRKA, TOVARNA ZDRAVIL, N.SOL.O. (YU) | 1985-11-05 | — | — | US | claimed |
| US-4478996-A | Process for the preparation of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides | MEDICHEM, S.A. (ES) | 1984-10-23 | — | — | US | claimed |
| US-4551525-A | Process for preparing N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide | KRKA, TOVARNA ZDRAVIL, N.SOL.O. (YU) | 1985-11-05 | — | — | US | disclosed |
| US-4551525-A | Process for preparing N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide | KRKA, TOVARNA ZDRAVIL, N.SOL.O. (YU) | 1985-11-05 | — | — | US | disclosed |
| EP-0076643-B1 | PROCESSES FOR PREPARING PIROXICAM AND INTERMEDIATES LEADING THERETO | PFIZER INC. (US) | 1985-02-20 | — | — | EP | disclosed |
| US-4483982-A | REACTING N-METHYLSACCHARIN WITH (N-2-PYRIDYL) HALOACETAMIDES OR ALKYLACETATES | PFIZER INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4483982-A | REACTING N-METHYLSACCHARIN WITH (N-2-PYRIDYL) HALOACETAMIDES OR ALKYLACETATES | PFIZER INC. (US) | 1984-11-20 | — | — | US | disclosed |
| US-4478996-A | Process for the preparation of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides | MEDICHEM, S.A. (ES) | 1984-10-23 | — | — | US | disclosed |
| US-4478996-A | Process for the preparation of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides | MEDICHEM, S.A. (ES) | 1984-10-23 | — | — | US | disclosed |
| EP-0076643-A1 | Processes for preparing piroxicam and intermediates leading thereto | PFIZER INC. (US) | 1983-04-13 | — | — | EP | disclosed |
| EP-0076643-A1 | Processes for preparing piroxicam and intermediates leading thereto | PFIZER INC. (US) | 1983-04-13 | — | — | EP | disclosed |
| US-4376204-A | 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam | PFIZER INC. (US) | 1983-03-08 | — | — | US | disclosed |
| US-4376204-A | 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam | PFIZER INC. (US) | 1983-03-08 | — | — | US | disclosed |