Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.58 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30218271 | 1.00 | HSD11B1 (0.73) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL6794794 | 0.85 | CAPN1 (0.57) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL3419653 | 0.85 | HSD11B1 (0.68) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL30822800 | 0.85 | HSD11B1 (1.00) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL2345581 | 0.85 | HSD11B1 (1.00) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL10964170 | 0.84 | HSD11B1 (0.75) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL2351157 | 0.83 | HSD11B1 (0.66) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL3495355 | 0.83 | HSD11B1 (0.66) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL10508168 | 0.82 | HSD11B1 (0.77) | HSD11B1PTGS1PTGS2KDM4EUSP2 | |
| SCHEMBL10957238 | 0.82 | HSD11B1 (0.58) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527282-B | 1, 2-benzothiazine heterocyclic derivative and preparation method and application thereof | 齐鲁医药学院 | 2023-02-07 | — | — | CN | claimed |
| CN-113527282-A | 1, 2-benzothiazine heterocyclic derivative and preparation method and application thereof | 齐鲁医药学院 | 2021-10-22 | — | — | CN | claimed |
| EP-0098422-B1 | PROCESS FOR PREPARING 4-HYDROXY-2-METHYL-N-2-PYRIDYL-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE 1,1-DIOXIDE | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1987-12-09 | — | — | EP | claimed |
| US-4474956-A | Process for the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1984-10-02 | — | — | US | claimed |
| US-4024136-A | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide | WARNER-LAMBERT COMPANY (US) | 1977-05-17 | — | — | US | claimed |
| US-3960856-A | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide | WARNER-LAMBERT COMPANY (US) | 1976-06-01 | — | — | US | claimed |
| JP-3005425-A | — | — | None | — | — | JP | disclosed |
| CN-113527282-B | 1, 2-benzothiazine heterocyclic derivative and preparation method and application thereof | 齐鲁医药学院 | 2023-02-07 | — | — | CN | disclosed |
| CN-113527282-A | 1, 2-benzothiazine heterocyclic derivative and preparation method and application thereof | 齐鲁医药学院 | 2021-10-22 | — | — | CN | disclosed |
| US-20210093642-A1 | STABLE AQUEOUS PARENTERAL SOLUTIONS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) | CADILA HEALTHCARE LIMITED (IN) | 2021-04-01 | — | — | US | disclosed |
| WO-2021059234-A1 | STABLE AQUEOUS PARENTERAL SOLUTIONS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) | CADILA HEALTHCARE LIMITED (IN) | 2021-04-01 | — | — | WO | disclosed |
| CN-103304513-B | One-class 1,2-benzothiazine compound as well as preparation method and application thereof | ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE | 2015-02-04 | — | — | CN | disclosed |
| CN-103271923-B | Medical application of benzothiazine derivative | ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE | 2014-11-26 | — | — | CN | disclosed |
| EP-0123418-A1 | 4-Hydroxy-N-(5((substituted hetero) methyl)-3-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide,1,1-dioxide and 4-hydroxy-2-alkyl-N-(5-((substituted hetero) methyl)-3-isoxazolyl)2H-1,2-benzothiazine-3-carboxamide,1,1-dioxide | WARNER-LAMBERT COMPANY (US) | 1984-10-31 | — | — | EP | disclosed |
| US-4474956-A | Process for the preparation of 4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1984-10-02 | — | — | US | disclosed |
| EP-0076643-A1 | Processes for preparing piroxicam and intermediates leading thereto | PFIZER INC. (US) | 1983-04-13 | — | — | EP | disclosed |
| US-4376204-A | 3-Hydroxy 2-methyl benzisothiazolines as intermediates in production of piroxicam | PFIZER INC. (US) | 1983-03-08 | — | — | US | disclosed |
| US-4233299-A | ANTIINFLAMMATORY AGENTS, ANTIPYRETICS | BOEHRINGER INGELHEIM GMBH (DE) | 1980-11-11 | — | — | US | disclosed |
| US-4024136-A | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide | WARNER-LAMBERT COMPANY (US) | 1977-05-17 | — | — | US | disclosed |
| US-3960856-A | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide | WARNER-LAMBERT COMPANY (US) | 1976-06-01 | — | — | US | disclosed |