SCHEMBL3419653

SCHEMBL3419653

CC(C)OC(=O)C1=C(O)c2ccccc2S(=O)(=O)N1C

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.68
PTGS1 P23219 3/20 0.52
PTGS2 P35354 3/20 0.52
KDM4E B2RXH2 2/20 0.52
USP2 O75604 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
ALOX15 P16050 1/20 0.52
NFKB1 P19838 1/20 0.52
CYP2C19 P33261 1/20 0.52
BLM P54132 1/20 0.52
SLC22A6 Q4U2R8 1/20 0.52
SLC22A8 Q8TCC7 1/20 0.52
MAPK1 P28482 1/20 0.51
PTGES O14684 1/20 0.49
LMNA P02545 1/20 0.49
KDR P35968 1/20 0.49
ABCB11 O95342 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6796426 0.85 HSD11B1 (0.73) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL30218271 0.85 HSD11B1 (0.73) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL30822800 0.81 HSD11B1 (1.00) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL2345581 0.81 HSD11B1 (1.00) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL3495355 0.80 HSD11B1 (0.66) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL2351157 0.80 HSD11B1 (0.66) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL11034692 0.80 HSD11B1 (0.73) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL10508168 0.79 HSD11B1 (0.77) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL10954111 0.79 HSD11B1 (0.81) HSD11B1PTGS1PTGS2KDM4EUSP2
SCHEMBL10958729 0.79 HSD11B1 (0.64) HSD11B1PTGS1PTGS2KDM4EUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113614077-A Meloxicam cocrystal 迈兰实验室有限公司 2021-11-05 CN disclosed
EP-2166060-B1 Stabilized aqueous polymer compositions TOUGAS OILFIELD SOLUTIONS GMBH (DE) 2016-08-10 EP disclosed
US-8962715-B2 Stabilized aqueous polymer compositions and their use TOUGAS OILFIELD SOLUTIONS GMBH (DE) 2015-02-24 US disclosed
US-20100075871-A1 Stabilized aqueous polymer compositions and their use TOUGAS HOLDING GMBH (DE) 2010-03-25 US disclosed
EP-2166060-A1 Stabilized aqueous polymer compositions and their use Allessa Chemie GmbH (DE) 2010-03-24 EP disclosed
EP-1462451-B1 NOVEL CRYSTALLINE FORMS OF MELOXICAM AND THE PREPARATION AND INTERCONVERSION METHODS THEREOF ESTEVE QUIMICA SA (ES) 2006-03-01 EP disclosed
US-6967248-B2 Crystalline forms of meloxicam and processes for their preparation and interconversion ESTEVE QUIMICA, SA (ES) 2005-11-22 US disclosed
EP-1462451-A1 NOVEL CRYSTALLINE FORMS OF MELOXICAM AND THE PREPARATION AND INTERCONVERSION METHODS THEREOF ESTEVE QUIMICA, S.A. (ES) 2004-09-29 EP disclosed
US-20030109701-A1 Crystalline forms of meloxicam and processes for their preparation and interconversion ESTEVE QUIMICA, S.A. (ES) 2003-06-12 US disclosed
US-4797483-A Process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide INDUSPOL, S.A. (ES) 1989-01-10 US disclosed
EP-0284514-A1 Process for obtaining 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide ESTEVE QUIMICA, S.A. (ES) 1988-09-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030109701-A1 Crystalline forms of meloxicam and processes for their preparation and interconversion CRYAA, CRYAB, TTR HSD11B1 2361/4885PTGS1 62/4885PTGS2 57/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.