Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569082 | 0.98 | NPC1 (0.63) | NPC1MAPTALDH1A1TSHRHPGD | |
| Hydrochloric Acid SCHEMBL10728839 | 0.97 | NPC1 (0.61) | NPC1MAPTALDH1A1TSHRHPGD | |
| SCHEMBL9170847 | 0.85 | MAPT (0.48) | NPC1MAPTALDH1A1TSHRHPGD | |
| SCHEMBL27777806 | 0.85 | HTR1A (0.52) | MAPTALDH1A1ABCB1GAAHTT | |
| SCHEMBL501560 | 0.85 | LMNA (0.53) | NPC1MAPTALDH1A1HPGDL3MBTL1 | |
| SCHEMBL27818370 | 0.85 | ADRB1 (0.51) | NPC1MAPTTSHRCYP1A2CYP2D6 | |
| SCHEMBL11665416 | 0.85 | NPC1 (0.59) | NPC1MAPTALDH1A1TSHRHPGD | |
| SCHEMBL4936194 | 0.84 | NPC1 (0.54) | NPC1MAPTALDH1A1TSHRHPGD | |
| SCHEMBL10854322 | 0.84 | NPC1 (0.50) | NPC1MAPTALDH1A1TSHRHPGD | |
| SCHEMBL30457496 | 0.84 | NPC1 (0.54) | NPC1MAPTALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260086062-A1 | IMMOBILIZATION STRATEGIES FOR ENHANCING SENSITIVITY OF ELECTROCHEMICAL APTAMER-BASED SENSORS | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2026-03-26 | — | — | US | claimed |
| US-20260086062-A1 | IMMOBILIZATION STRATEGIES FOR ENHANCING SENSITIVITY OF ELECTROCHEMICAL APTAMER-BASED SENSORS | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2026-03-26 | — | — | US | disclosed |
| WO-2023170687-A1 | BACTERIAL COMPOSITION FOR USE IN TREATMENT OF SUBSTANCE USE DISORDER | BAR-ILAN UNIVERSITY (IL) | 2023-09-14 | — | — | WO | disclosed |
| CN-110187016-A | A kind of analysis method of cassie letones in dried blood sample | 司法鉴定科学研究院 | 2019-08-30 | — | — | CN | disclosed |
| US-9938276-B2 | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-04-10 | — | — | US | disclosed |
| US-20170320874-A1 | 6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-09 | — | — | US | disclosed |
| US-9671415-B2 | Immunoassay for pyrrolidinophenones | RANDOX LABORATORIES LIMITED (GB) | 2017-06-06 | — | — | US | disclosed |
| US-20160097783-A1 | IMMUNOASSAY FOR PYRROLIDINOPHENONES | NORTHERN BANK LIMITED (IE) | 2016-04-07 | — | — | US | disclosed |
| US-8399480-B2 | Hydroxymethyl pyrrolidines as beta 3 adrenergic receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120258963-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. | 2012-10-11 | — | — | US | disclosed |
| US-20110028481-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. | 2011-02-03 | — | — | US | disclosed |
| US-20090253705-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC | 2009-10-08 | — | — | US | disclosed |
| EP-0150235-A1 | Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1985-08-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028481-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | NPC1 2654/4885MAPT 3296/4885ALDH1A1 369/4885 |
| US-20120258963-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | NPC1 2654/4885MAPT 3296/4885ALDH1A1 369/4885 |
| US-20090253705-A1 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS | ADRB3, ADRB1, ADRB2 | NPC1 2654/4885MAPT 3296/4885ALDH1A1 369/4885 |
| US-20160097783-A1 | IMMUNOASSAY FOR PYRROLIDINOPHENONES | CYP2D6, CYP2B6, CYP3A43 | NPC1 4602/4885MAPT 2162/4885ALDH1A1 306/4885 |
| US-20170320874-A1 | 6,5-BICYCLIC OCTAHYDROPYRROLOPYRIDINE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY5R | NPC1 1014/4885MAPT 1128/4885ALDH1A1 2028/4885 |
| US-20260086062-A1 | IMMOBILIZATION STRATEGIES FOR ENHANCING SENSITIVITY OF ELECTROCHEMICAL APTAMER-BASED SENSORS | EBPL, ADA, XBP1 | NPC1 4559/4885MAPT 1108/4885ALDH1A1 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.