Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11973683 | 0.70 | SLC40A1 (1.00) | SLC40A1ALDH1A1HTTLMNAMAPT | |
| SCHEMBL3635774 | 0.68 | ALOX15 (0.58) | ALDH1A1HTTMAPTPKML3MBTL1 | |
| SCHEMBL11410717 | 0.66 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTPKML3MBTL1 | |
| SCHEMBL1142036 | 0.65 | MAPT (0.57) | ALDH1A1MAPTL3MBTL1MAPK1MEN1 | |
| SCHEMBL8752451 | 0.65 | ALDH1A1 (0.63) | ALDH1A1HTTLMNAMAPTL3MBTL1 | |
| SCHEMBL12750190 | 0.65 | L3MBTL1 (0.56) | ALDH1A1LMNAMAPTL3MBTL1MAPK1 | |
| SCHEMBL8752535 | 0.64 | LMNA (0.64) | ALDH1A1HTTLMNAMAPTL3MBTL1 | |
| SCHEMBL8752408 | 0.64 | LMNA (0.64) | SLC40A1ALDH1A1HTTLMNAMAPT | |
| SCHEMBL18710026 | 0.64 | SLC40A1 (0.46) | SLC40A1ALDH1A1LMNAMAPTPKM | |
| SCHEMBL22619105 | 0.63 | SLC40A1 (0.51) | SLC40A1ALDH1A1MAPTPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014642-B1 | OPHTHALMIC COMPOSITIONS COMPRISING COMBINATIONS OF CARBONIC ANHYDRASE INHIBITORS AND S-(-)-1-(TERT-BUTYLAMINO)-3-(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)-OXY-2-PROPANOL FOR TOPICAL APPLICATION IN THE TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1984-03-21 | — | — | EP | claimed |