Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 6/20 | 1.00 |
| ▸ | AKR1C2 | P52895 | 5/20 | 1.00 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.57 |
| ▸ | AR | P10275 | 2/20 | 0.57 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29481380 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| Acetic Acid SCHEMBL11761270 | 0.96 | AKR1C3 (0.93) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| SCHEMBL16746715 | 0.89 | AKR1C3 (0.81) | AKR1C3AKR1C2TUBB1PTGS1KDM4E | |
| SCHEMBL29596462 | 0.89 | AKR1C3 (0.80) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| SCHEMBL5268342 | 0.88 | AKR1C3 (0.78) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| SCHEMBL10788768 | 0.88 | AKR1C3 (0.78) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| SCHEMBL11262826 | 0.88 | AKR1C3 (0.78) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| SCHEMBL11086794 | 0.87 | AKR1C3 (0.76) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| SCHEMBL29941900 | 0.87 | AKR1C3 (0.77) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 | |
| SCHEMBL15684644 | 0.87 | AKR1C3 (0.77) | AKR1C3AKR1C2TUBB1PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0047358-B1 | INDOL ACETIC DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1984-09-19 | — | — | EP | claimed |
| JP-58164574-A | — | — | None | — | — | JP | disclosed |
| JP-58164572-A | — | — | None | — | — | JP | disclosed |
| JP-58164571-A | — | — | None | — | — | JP | disclosed |
| JP-58164573-A | — | — | None | — | — | JP | disclosed |
| US-20210198197-A1 | METHOD FOR SYNTHESIZING INDOMETHACIN AND ANALOGUE THEREOF | HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-07-01 | — | — | US | disclosed |
| WO-2014083476-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIPID DISORDERS | KANDULA MAHESH (IN) | 2014-06-05 | — | — | WO | disclosed |
| US-8728493-B2 | Polymer based compositions and conjugates of non-steroidal anti-inflammatory drugs | NEKTAR THERAPEUTICS (US) | 2014-05-20 | — | — | US | disclosed |
| US-8728493-B2 | Polymer based compositions and conjugates of non-steroidal anti-inflammatory drugs | NEKTAR THERAPEUTICS (US) | 2014-05-20 | — | — | US | disclosed |
| US-20070025956-A1 | Polymer-based compositions and conjugates of non-steroidal anti-inflammatory drugs | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-02-01 | — | — | US | disclosed |
| US-20070025956-A1 | Polymer-based compositions and conjugates of non-steroidal anti-inflammatory drugs | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-02-01 | — | — | US | disclosed |
| JP-S58164574-A | MANUFACTURE OF 1-(4-CHLOROBENZOYL)-5-METHOXY- 2-METHYL-3-INDOLE ACETOXYACETIC ACIDS | TROPONWERKE GMBH & CO KG | 1983-09-29 | — | — | JP | disclosed |
| JP-S58164571-A | MANUFACTURE OF 1-(4-CHLOROBENZOYL)-5-METHOXY- 2-METHYL-3-INDOLE ACETOXYACETIC ACIDS | TROPONWERKE GMBH & CO KG | 1983-09-29 | — | — | JP | disclosed |
| JP-S58164572-A | MANUFACTURE OF 1-(4-CHLOROBENZOYL)-5-METHOXY- 2-METHYL-3-INDOLE ACETOXYACETIC ACIDS | TROPONWERKE GMBH & CO KG | 1983-09-29 | — | — | JP | disclosed |
| JP-S58164573-A | MANUFACTURE OF 1-(4-CHLOROBENZOYL)-5-METHOXY- 2-METHYL-3-INDOLE ACETOXYACETIC ACIDS | TROPONWERKE GMBH & CO KG | 1983-09-29 | — | — | JP | disclosed |
| US-4003990-A | Anti-inflammatory polymers, pharmaceutical compositions containing the same and process for producing said polymers | SOCIETE ANONYME DITE: L'OREAL (FR) | 1977-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070025956-A1 | Polymer-based compositions and conjugates of non-steroidal anti-inflammatory drugs | HPGDS, PTGES, PTGS1 | AKR1C3 1272/4885AKR1C2 1308/4885TUBB1 588/4885 |
| US-20210198197-A1 | METHOD FOR SYNTHESIZING INDOMETHACIN AND ANALOGUE THEREOF | IDO1, IDO2, PTGIS | AKR1C3 214/4885AKR1C2 567/4885TUBB1 4509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.