SCHEMBL11039717

SCHEMBL11039717

CCOC1=NC=Cc2cc(OC)c(OC)cc2C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.41
MAPT P10636 2/20 0.39
CYP3A4 P08684 1/20 0.39
PDE4D Q08499 2/20 0.35
ALDH1A1 P00352 5/20 0.33
KDM4E B2RXH2 4/20 0.33
GAA P10253 1/20 0.33
GLA P06280 2/20 0.33
MAOA P21397 2/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
KMT2A Q03164 2/20 0.32
ENPP1 P22413 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
ALOX15 P16050 1/20 0.32
MAPK1 P28482 1/20 0.32
MEN1 O00255 1/20 0.32
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11041298 0.86 BRD4 (0.46) BRD4MAPTCYP3A4ALDH1A1KDM4E
SCHEMBL11042221 0.82 ALDH1A1 (0.33) MAPTALDH1A1
SCHEMBL11057303 0.82 MAPT (0.40) BRD4MAPTCYP3A4PDE4DALDH1A1
SCHEMBL11040367 0.82 MAPT (0.40) BRD4MAPTCYP3A4PDE4DALDH1A1
Hydrochloric Acid SCHEMBL11051850 0.81 MAPT (0.42) BRD4MAPTCYP3A4PDE4DALDH1A1
Hydrochloric Acid SCHEMBL11059748 0.81 MAPT (0.42) BRD4MAPTCYP3A4PDE4DALDH1A1
SCHEMBL11055073 0.79 POLB (0.32)
SCHEMBL11063789 0.75 BRD4 (0.40) BRD4MAPTCYP3A4ALDH1A1KDM4E
SCHEMBL11041640 0.75 BRD4 (0.45) BRD4MAPTCYP3A4ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL11057868 0.75 PDGFRB (0.35) BRD4MAPTPDE4DALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0116444-A2 Improvements in or relating to benzazepine derivatives ELI LILLY AND COMPANY (US) 1984-08-22 EP claimed
EP-0116444-A2 Improvements in or relating to benzazepine derivatives ELI LILLY AND COMPANY (US) 1984-08-22 EP disclosed