Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Tyrosol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.45 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.45 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.44 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.44 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.44 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.71 |
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosol SCHEMBL43838 | 0.84 | CA2 (1.00) | CA2ESR1ESR2CA1CA12 | |
| SCHEMBL6991230 | 0.83 | CA2 (0.52) | CA2CA1CA12CA4CA6 | |
| Tyrosol SCHEMBL28157257 | 0.82 | CA2 (0.94) | CA2ESR1ESR2CA1CA12 | |
| Tyrosol SCHEMBL27940319 | 0.82 | CA2 (0.94) | CA2ESR1ESR2CA1CA12 | |
| Tyrosol SCHEMBL28609607 | 0.82 | CA2 (0.94) | CA2ESR1ESR2TMEM97SIGMAR1 | |
| SCHEMBL4228481 | 0.82 | CA2 (0.50) | CA2CA1CA12CA4CA6 | |
| SCHEMBL5584817 | 0.82 | CA2 (0.50) | CA2CA1CA12CA4CA6 | |
| Phenylethyl Alcohol SCHEMBL27373999 | 0.81 | TDP1 (0.70) | CA2CA1CA12CA4CA6 | |
| Tyrosol SCHEMBL303517 | 0.80 | CA2 (0.81) | CA2ESR1ESR2TMEM97SIGMAR1 | |
| Hydroquinone SCHEMBL28903112 | 0.79 | ENPP2 (0.65) | CA2ESR1ESR2CA1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4490165-A | Meta-(phenylalkoxy)phenyl-N-methoxy-N-methylurea compounds, methods for preparing same and herbicidal use thereof | AMERICAN CYANAMID COMPANY (US) | 1984-12-25 | — | — | US | disclosed |
| US-4308213-A | Meta-(phenylalkoxy)phenyl-N-methoxy-N-methylurea compounds | AMERICAN CYANAMID COMPANY (US) | 1981-12-29 | — | — | US | disclosed |