Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 4/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11041485 | 0.78 | BRD4 (0.44) | NPSR1ALDH1A1SMN1; SMN2ADORA1MAPT | |
| SCHEMBL11037216 | 0.76 | GRIN2D (0.41) | NPSR1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL11037212 | 0.76 | DRD1 (0.39) | NPSR1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11040857 | 0.75 | DRD1 (0.41) | KDM4EALDH1A1HPGDADORA1MAPT | |
| SCHEMBL10743293 | 0.72 | MTNR1B (0.42) | NPSR1KDM4EALDH1A1SMN1; SMN2ADORA1 | |
| SCHEMBL1317721 | 0.70 | KDM4E (0.61) | NPSR1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL28736739 | 0.69 | ALDH1A1 (0.65) | NPSR1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL12841360 | 0.69 | TYMS (0.55) | NPSR1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1462814 | 0.68 | KCNH2 (0.60) | NPSR1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1463663 | 0.67 | KCNH2 (0.59) | NPSR1KDM4EALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040401-B1 | TRIAZOLOQUINOXALIN-4-ONES AND SUCH OXALINE-4-THIONES | USV PHARMACEUTICAL CORPORATION (US) | 1984-03-21 | — | — | EP | disclosed |
| US-4354027-A | HYPOTENSIVE AGENTS | USV PHARMACEUTICAL CORPORATION (US) | 1982-10-12 | — | — | US | disclosed |
| EP-0040401-A1 | Triazoloquinoxalin-4-ones and such oxaline-4-thiones | USV PHARMACEUTICAL CORPORATION (US) | 1981-11-25 | — | — | EP | disclosed |