Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | TYMP | P19971 | 3/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1925551 | 0.94 | TYR (0.37) | HTR1AHTR1DHTR1BTYMPGPR84 | |
| SCHEMBL27976370 | 0.92 | TYR (0.40) | HTR1AHTR1DHTR1BTYMPGPR84 | |
| SCHEMBL27976364 | 0.88 | HTT (0.35) | HTR1AHTR1DHTR1BTYMPTYR | |
| SCHEMBL11041595 | 0.80 | TYMP (0.34) | CYP19A1TYMPGPR84CYP3A4PTGS2 | |
| SCHEMBL30294022 | 0.74 | TYR (0.41) | HTR1AHTR1DHTR1BTYMPGPR84 | |
| Hydrochloric Acid SCHEMBL28555353 | 0.73 | TYR (0.40) | HTR1AHTR1DHTR1BTYMPGPR84 | |
| SCHEMBL10755010 | 0.73 | LIPG (0.38) | HTR1AHTR1DHTR1BTYMPGPR84 | |
| SCHEMBL9287050 | 0.72 | GPR84 (0.34) | TYMPGPR84TYRCYP3A4PTGS2 | |
| SCHEMBL28234439 | 0.71 | GPR84 (0.37) | HTR1AHTR1DHTR1BTYMPGPR84 | |
| SCHEMBL9015218 | 0.70 | MAPT (0.39) | KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034798-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-(SUBSTITUTED-THIO)PYRROLES AND THEIR CORRESPONDING SULFOXIDES AND SULFONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-05-22 | — | — | EP | disclosed |
| EP-0005156-B1 | 4,5-DIARYL-2-(SUBSTITUTED-THIO)-PYRROLES AND THEIR CORRESPONDING SULFOXIDES AND SULFONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-09-22 | — | — | EP | disclosed |
| EP-0034798-A2 | Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-09-02 | — | — | EP | disclosed |
| US-4267184-A | USEFUL FOR TREATING ARTHRITIS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-05-12 | — | — | US | disclosed |
| EP-0005156-A1 | 4,5-diaryl-2-(substituted-thio)-pyrroles and their corresponding sulfoxides and sulfones, process for their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-11-14 | — | — | EP | disclosed |