Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | BID | P55957 | 3/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.33 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27976370 | 0.98 | TYR (0.40) | TYRHTR1AHTR1DHTR1BLIPG | |
| SCHEMBL11041473 | 0.94 | HTR1A (0.35) | TYRHTR1AHTR1DHTR1BLIPG | |
| SCHEMBL27976364 | 0.94 | HTT (0.35) | TYRHTR1AHTR1DHTR1BMAPT | |
| SCHEMBL11041595 | 0.82 | TYMP (0.34) | TP53CYP3A4ALOX5TYMPGPR84 | |
| SCHEMBL30294022 | 0.80 | TYR (0.41) | TYRHTR1AHTR1DHTR1BLIPG | |
| SCHEMBL10755010 | 0.78 | LIPG (0.38) | TYRHTR1AHTR1DHTR1BLIPG | |
| Hydrochloric Acid SCHEMBL28555353 | 0.78 | TYR (0.40) | TYRHTR1AHTR1DHTR1BLIPG | |
| SCHEMBL9679897 | 0.76 | MAPT (0.39) | TYRHTR1AHTR1DHTR1BLIPG | |
| SCHEMBL9015242 | 0.74 | MAPT (0.38) | HTR1AHTR1DHTR1BLIPGMAPT | |
| SCHEMBL9287050 | 0.73 | GPR84 (0.34) | TYRTP53CYP3A4TYMPGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005024058-A2 | COMPOUNDS FOR THE TREATMENT OF DISEASES INVOLVING COGNITIVE IMPAIRMENT, SUCH AS ALZHEIMER’S DISEASE, AND METHODS FOR IDENTIFYING SUCH COMPOUNDS | GALAPAGOS N.V. (BE) | 2005-03-17 | — | — | WO | claimed |
| CN-116348105-A | Pharmaceutically acceptable salts of arylpyrrole derivatives | 圣提内尔肿瘤学有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-114585605-A | Pharmaceutical compounds | 圣提内尔肿瘤学有限公司 | 2022-06-03 | — | — | CN | disclosed |
| EP-1431293-B1 | WATER-SOLUBLE PHENYLPYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | KOWA CO (JP) | 2011-06-08 | — | — | EP | disclosed |
| US-20090270399-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | KOWA CO., LTD. (JP) | 2009-10-29 | — | — | US | disclosed |
| EP-1043317-B1 | PYRIDAZINE DERIVATIVES AND MEDICAMENTS CONTAINING THEM AS ACTIVE INGREDIENT | KOWA CO (JP) | 2009-04-15 | — | — | EP | disclosed |
| US-20090069332-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | KOWA CO., LTD. (JP) | 2009-03-12 | — | — | US | disclosed |
| EP-2017266-A1 | Pyridazine derivatives and medicines containing the same as effective ingredients | Kowa Co., Ltd. (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-20080119474-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | KOWA CO., LTD. (JP) | 2008-05-22 | — | — | US | disclosed |
| US-20070208025-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | KOWA CO., LTD. (JP) | 2007-09-06 | — | — | US | disclosed |
| EP-1196167-A1 | METHOD OF REDUCING NEURONAL INJURY OR APOPTOSIS | Lipton, Stuart A. (US) | 2002-04-17 | — | — | EP | disclosed |
| US-6348468-B1 | THESE COMPOUNDS HAVE EXCELLENT INHIBITORY ACTIVITY AGAINST INTERLEUKIN-1.BETA. PRODUCTION, IMMUNE SYSTEM DISEASES, INFLAMMATORY DISEASES, ISCHEMIC DISEASES AND THE LIKE. | KOWA CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| EP-1178981-A1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2002-02-13 | — | — | EP | disclosed |
| EP-1156039-A1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2001-11-21 | — | — | EP | disclosed |
| WO-2001001986-A1 | METHOD OF REDUCING NEURONAL INJURY OR APOPTOSIS | LIPTON STUART A (US) | 2001-01-11 | — | — | WO | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |
| WO-2000069847-A1 | SUBSTITUTED 3-PYRIDYL-4-ARYLPYRROLES, AND RELATED THERAPEUTIC AND PROPHYLACTIC METHODS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-11-23 | — | — | WO | disclosed |
| EP-1043317-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-10-11 | — | — | EP | disclosed |
| US-5387693-A | Intermediates for inhibitors of cholesterol biosynthesis | ORTHO PHARMACEUTICAL CORPORATION (US) | 1995-02-07 | — | — | US | disclosed |
| US-5134155-A | Anticholesterol | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208025-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | IL1B, IL1R1, TLR1 | TYR 1256/4885HTR1A 1114/4885HTR1D 1835/4885 |
| US-20090270399-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | IL1B, IL1R1, TLR1 | TYR 1308/4885HTR1A 974/4885HTR1D 1630/4885 |
| US-20090069332-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | IL1B, IL1R1, TLR1 | TYR 1308/4885HTR1A 974/4885HTR1D 1630/4885 |
| US-20080119474-A1 | NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS | IL1B, IL1R1, TLR1 | TYR 1256/4885HTR1A 1114/4885HTR1D 1835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.