Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 3/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CCR5 | P51681 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.31 |
| ▸ | TACR2 | P21452 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9287050 | 0.83 | GPR84 (0.34) | TYMPGPR84PTGS2CYP3A4KDM4E | |
| SCHEMBL14341156 | 0.83 | HTT (0.35) | TYMPKDM4EHPGD | |
| SCHEMBL1925551 | 0.82 | TYR (0.37) | TYMPGPR84CYP3A4ALOX5TP53 | |
| SCHEMBL28234439 | 0.82 | GPR84 (0.37) | TYMPGPR84PTGS2CYP3A4KDM4E | |
| SCHEMBL18850562 | 0.81 | TYMP (0.35) | TYMPGPR84CYP19A1PTGS2CYP3A4 | |
| SCHEMBL27976370 | 0.80 | TYR (0.40) | TYMPGPR84CYP3A4ALOX5TP53 | |
| SCHEMBL11041473 | 0.80 | HTR1A (0.35) | TYMPGPR84CYP19A1PTGS2CYP3A4 | |
| SCHEMBL27976364 | 0.75 | HTT (0.35) | TYMPKDM4EHPGD | |
| SCHEMBL8740890 | 0.74 | HTT (0.38) | TYMPKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL9015218 | 0.73 | MAPT (0.39) | KDM4EALDH1A1GAAESR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317286-B1 | CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2019-09-11 | — | — | EP | disclosed |
| EP-0034798-B1 | ANTIINFLAMMATORY 4,5-DIARYL-2-(SUBSTITUTED-THIO)PYRROLES AND THEIR CORRESPONDING SULFOXIDES AND SULFONES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-05-22 | — | — | EP | disclosed |
| US-4495196-A | Antiinflammatory 4,5-diaryl-α-polyfluoroalkyl-1H-pyrrole-2-methanols and method for use thereof | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0038536-B1 | ANTIINFLAMMATORY 4,5-DIARYL-ALPHA-(POLYFLUOROALKYL)-1H-PYRROLE-2-METHANAMINES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-02-01 | — | — | EP | disclosed |
| EP-0005156-B1 | 4,5-DIARYL-2-(SUBSTITUTED-THIO)-PYRROLES AND THEIR CORRESPONDING SULFOXIDES AND SULFONES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-09-22 | — | — | EP | disclosed |
| US-4335136-A | Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-06-15 | — | — | US | disclosed |
| EP-0038536-A1 | Antiinflammatory 4,5-diaryl-alpha-(polyfluoroalkyl)-1H-pyrrole-2-methanamines | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-10-28 | — | — | EP | disclosed |
| EP-0034798-A2 | Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-09-02 | — | — | EP | disclosed |
| US-4267190-A | AND METHOD OF ADMINISTERING TO MAMMALS FOR TREATMENT OF ARTHRITIS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-05-12 | — | — | US | disclosed |
| US-4267184-A | USEFUL FOR TREATING ARTHRITIS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-05-12 | — | — | US | disclosed |
| EP-0025884-A1 | 4,5-Diaryl-alpha-polyfluoroalkyl-1H-pyrrole-2-methanols and 1-(4,5-diaryl-1H-pyrrol-2-yl)-polyfluoroalkanones, processes for preparing them and pharmaceutical compositions | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-04-01 | — | — | EP | disclosed |
| EP-0005156-A1 | 4,5-diaryl-2-(substituted-thio)-pyrroles and their corresponding sulfoxides and sulfones, process for their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-11-14 | — | — | EP | disclosed |