Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040309 | 0.82 | ALDH1A1 (0.41) | PLA2G2ALMNACYP1A2CES2CES1 | |
| SCHEMBL11046033 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDRAB9AL3MBTL1CA1 | |
| SCHEMBL2424023 | 0.78 | CA1 (0.41) | SMN1; SMN2HPGDRAB9AL3MBTL1CA1 | |
| Hydrochloric Acid SCHEMBL11220307 | 0.77 | HTT (0.41) | SMN1; SMN2LMNAKMT2AMAPT | |
| SCHEMBL31446707 | 0.75 | AKR1C3 (0.52) | SMN1; SMN2HPGDRAB9AL3MBTL1CA1 | |
| SCHEMBL11039504 | 0.75 | CES2 (0.49) | KDM4ECES2CES1 | |
| SCHEMBL10500095 | 0.74 | CA1 (0.41) | SMN1; SMN2HPGDRAB9AL3MBTL1CA1 | |
| SCHEMBL4860223 | 0.74 | CA1 (0.50) | SMN1; SMN2L3MBTL1CA1CA2CA12 | |
| SCHEMBL8830236 | 0.74 | ALDH1A1 (0.46) | SMN1; SMN2HPGDRAB9AL3MBTL1LMNA | |
| SCHEMBL12985782 | 0.73 | KDM4E (0.46) | SMN1; SMN2HPGDRAB9AL3MBTL1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| EP-0032242-B1 | 4H-3,1-BENZOXAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN INHIBITING THE GROWTH OF UNWANTED PLANTS | BASF Aktiengesellschaft (DE) | 1983-12-14 | — | — | EP | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |