Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.36 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11041856 | 0.78 | PLA2G2A (0.47) | SMN1; SMN2HPGDRAB9AL3MBTL1KDM4E | |
| SCHEMBL28738708 | 0.74 | CXCL8 (0.39) | SMN1; SMN2HPGDRAB9AL3MBTL1KMT2A | |
| SCHEMBL31446707 | 0.70 | AKR1C3 (0.52) | SMN1; SMN2HPGDRAB9AL3MBTL1KDM4E | |
| SCHEMBL10500095 | 0.69 | CA1 (0.41) | SMN1; SMN2HPGDRAB9AL3MBTL1KDM4E | |
| SCHEMBL2424023 | 0.69 | CA1 (0.41) | SMN1; SMN2HPGDRAB9AL3MBTL1KDM4E | |
| SCHEMBL8830236 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2HPGDRAB9AL3MBTL1PDE4D | |
| SCHEMBL12985782 | 0.68 | KDM4E (0.46) | SMN1; SMN2HPGDRAB9AL3MBTL1KDM4E | |
| SCHEMBL27796522 | 0.67 | CA12 (0.55) | SMN1; SMN2HPGDRAB9AL3MBTL1KDM4E | |
| SCHEMBL28047480 | 0.67 | CA1 (0.41) | SMN1; SMN2HPGDRAB9AL3MBTL1KDM4E | |
| SCHEMBL9530930 | 0.65 | GLS (0.48) | SMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |