Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039504 | 0.87 | CES2 (0.49) | ALDH1A1CES2CES1 | |
| SCHEMBL11041856 | 0.82 | PLA2G2A (0.47) | LMNAKMT2AMAPTCES2CES1 | |
| SCHEMBL21165392 | 0.78 | ALDH1A1 (0.41) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL7291902 | 0.78 | AKR1B1 (0.42) | ALDH1A1CXCL8LMNAADRA2AMEN1 | |
| SCHEMBL8830155 | 0.78 | ALDH1A1 (0.41) | ALDH1A1CXCL8LMNAADRA2AMEN1 | |
| SCHEMBL6260569 | 0.77 | CXCL8 (0.53) | ALDH1A1CXCL8LMNAADRA2AMEN1 | |
| SCHEMBL67881 | 0.77 | ALDH1A1 (0.50) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL5065343 | 0.77 | CASP1 (0.49) | ALDH1A1CXCL8CYP2D6HIF1ACYP2C9 | |
| SCHEMBL5065346 | 0.77 | CASP1 (0.49) | ALDH1A1CXCL8CYP2D6HIF1ACYP2C9 | |
| SCHEMBL7464198 | 0.74 | CES2 (0.62) | ALDH1A1CES2CES1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |