SCHEMBL8830236

SCHEMBL8830236

COc1ccccc1NC(C(N)=O)c1c(Cl)cccc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
MAPT P10636 6/20 0.44
GAA P10253 4/20 0.44
POLB P06746 2/20 0.44
RECQL P46063 1/20 0.44
PDE4D Q08499 1/20 0.44
HTT P42858 1/20 0.44
FABP4 P15090 1/20 0.43
NPC1 O15118 1/20 0.43
CASP3 P42574 1/20 0.43
ATM Q13315 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
VDR P11473 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14440013 0.80 CXCL8 (0.43) ALDH1A1MAPTHTTCYP1A2LMNA
SCHEMBL8830164 0.80 KDM4E (0.43) ALDH1A1MAPTHTTNPC1CASP3
SCHEMBL11481793 0.78 KDM4E (0.51) ALDH1A1MAPTGAAPOLBNPC1
SCHEMBL9031893 0.78 ELANE (0.41) ALDH1A1POLBNPC1CASP3ATM
SCHEMBL9031280 0.76 CXCL8 (0.49) ALDH1A1MAPTPOLBHTTCYP1A2
SCHEMBL5967627 0.76 PTGS2 (0.44) ALDH1A1MAPTGAAHTTCYP3A4
SCHEMBL9029988 0.75 ALDH1A1 (0.43) ALDH1A1MAPTHTTNPC1CASP3
SCHEMBL19982730 0.75 ALDH1A1 (0.57) ALDH1A1MAPTGAAPOLBHTT
SCHEMBL377354 0.75 MAPT (0.46) ALDH1A1MAPTGAAHTTNPC1
SCHEMBL9246536 0.75 MAPT (0.46) ALDH1A1MAPTGAAHTTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684049-A HIV-inhibiting benzeneacetamide derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1997-11-04 US disclosed
EP-0538301-B1 HIV-INHIBITING BENZENEACETAMIDE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 1996-10-30 EP disclosed
US-5556886-A VIRICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-17 US disclosed
EP-0538301-A1 HIV-INHIBITING BENZENEACETAMIDE DERIVATIVES. JANSSEN PHARMACEUTICA NV (BE) 1993-04-28 EP disclosed
WO-1992000952-A1 HIV-INHIBITING BENZENEACETAMIDE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1992-01-23 WO disclosed