Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | XIAP | P98170 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11041567 | 0.87 | PPARD (0.43) | PTGS2PPARDPPARGPPARAALDH1A1 | |
| SCHEMBL11040129 | 0.86 | PPARA (0.58) | PTGS2PPARDPPARGPPARAALDH1A1 | |
| SCHEMBL11301950 | 0.82 | ALDH1A1 (0.47) | PTGS2PPARDPPARGPPARAALDH1A1 | |
| SCHEMBL11042391 | 0.75 | PTGS2 (0.54) | PTGS2PPARDPPARGPPARAALDH1A1 | |
| SCHEMBL11042394 | 0.74 | PTGS2 (0.49) | PTGS2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL11352115 | 0.73 | POLB (0.55) | PPARAALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL11045896 | 0.73 | ALDH1A1 (0.55) | PTGS2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL11752429 | 0.72 | SLC22A12 (0.52) | PTGS2PPARAALDH1A1MAPTCYP1A2 | |
| SCHEMBL11750819 | 0.72 | GAA (0.52) | PTGS2ALDH1A1MAPTCYP1A2CYP2D6 | |
| SCHEMBL11747669 | 0.72 | PPARA (0.56) | PTGS2PPARDPPARGPPARAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |