Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11401431 | 0.91 | ALDH1A1 (0.32) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11038529 | 0.86 | HSD17B10 (0.33) | MAPTKDM4EHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL11257718 | 0.81 | SMN1; SMN2 (0.45) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11257732 | 0.77 | MEN1 (0.46) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL6959645 | 0.74 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL6955861 | 0.73 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11258369 | 0.71 | SMN1; SMN2 (0.43) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL10923076 | 0.70 | KDM4E (0.40) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL10911579 | 0.69 | ALDH1A1 (0.39) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11039837 | 0.68 | LMNA (0.36) | ALDH1A1MAPTNPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042566-B1 | 4,4-DISUBSTITUTED 1,4-DIHYDROPYRIDINES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICAMENTS | BAYER AG (DE) | 1984-09-05 | — | — | EP | disclosed |
| EP-0042569-B1 | 4,4-DISUBSTITUTED SPIRO-1,4-DIHYDROPYRIDINES, PROCESS FOR PRODUCING THEM AND THEIR USE AS INTERMEDIATES | BAYER AG (DE) | 1983-10-12 | — | — | EP | disclosed |
| EP-0042566-A1 | 4,4-Disubstituted 1,4-dihydropyridines, process for their preparation and their use in medicaments | BAYER AG (DE) | 1981-12-30 | — | — | EP | disclosed |
| EP-0042569-A1 | 4,4-Disubstituted spiro-1,4-dihydropyridines, process for producing them and their use as intermediates | BAYER AG (DE) | 1981-12-30 | — | — | EP | disclosed |