Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 8/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039373 | 0.94 | ADRB1 (0.55) | ADRB1ADRB2ADRB3KDM4EGAA | |
| SCHEMBL10731106 | 0.88 | PNMT (0.47) | ADRB1ADRB2ADRB3 | |
| SCHEMBL6540063 | 0.87 | ADRB1 (0.49) | ADRB1ADRB2ADRB3KDM4EGAA | |
| SCHEMBL6540069 | 0.87 | ADRB1 (0.49) | ADRB1ADRB2ADRB3KDM4EGAA | |
| SCHEMBL11106888 | 0.87 | ADRB1 (0.44) | ADRB1ADRB2ADRB3KDM4EGAA | |
| SCHEMBL10890639 | 0.86 | PNMT (0.48) | ADRB1ADRB2KDM4EGAAALDH1A1 | |
| SCHEMBL11039327 | 0.84 | ADRB1 (0.48) | ADRB1ADRB2ADRB3 | |
| SCHEMBL11039896 | 0.84 | ADRB2 (0.47) | ADRB1ADRB2ADRB3KDM4EGAA | |
| SCHEMBL11184611 | 0.84 | ADRB3 (0.65) | ADRB1ADRB2ADRB3 | |
| SCHEMBL11352104 | 0.83 | ADRB1 (0.46) | ADRB1ADRB2ADRB3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040915-B1 | ARYLETHANOLAMINE DERIVATIVES, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | BEECHAM GROUP PLC (GB) | 1984-03-21 | — | — | EP | disclosed |
| US-4385066-A | DIETETICS, HYPERGLYCEMIC AGENTS ANTIINFLAMMATORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1983-05-24 | — | — | US | disclosed |
| EP-0040915-A1 | Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1981-12-02 | — | — | EP | disclosed |