SCHEMBL11044512

SCHEMBL11044512

O=C1C(=O)N(Cc2ccc(Nc3ncccn3)cc2)CCN1Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.46
MAPK1 P28482 1/20 0.43
DHPS P49366 2/20 0.42
STAT6 P42226 1/20 0.42
CDK4 P11802 1/20 0.41
CCND1 P24385 1/20 0.41
CCND2 P30279 1/20 0.41
CCND3 P30281 1/20 0.41
POLB P06746 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.41
P2RX7 Q99572 1/20 0.40
KCNH2 Q12809 1/20 0.40
GRM2 Q14416 1/20 0.40
PLK4 O00444 1/20 0.40
ALDH1A1 P00352 1/20 0.40
DDB1 Q16531 1/20 0.39
CRBN Q96SW2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11050060 0.96 P2RX7 (0.40) L3MBTL1MAPK1STAT6P2RX7GRM2
SCHEMBL11044711 0.90 P2RX7 (0.49) MAPK1STAT6P2RX7
SCHEMBL11049173 0.85 HDAC6 (0.45) L3MBTL1DHPSSTAT6CDK4CCND1
SCHEMBL11049109 0.84 ALDH1A1 (0.41) MAPK1POLBCYP2D6CYP2C9CYP2C19
SCHEMBL11049747 0.79 BLK (0.49) POLBALDH1A1TSHR
SCHEMBL11052192 0.78 KMT2A (0.59) L3MBTL1MAPK1POLBCYP2D6CYP2C9
SCHEMBL11052061 0.77 MET (0.49) L3MBTL1P2RX7DDB1CRBN
SCHEMBL11050145 0.74 MEN1 (0.62) L3MBTL1POLBKMT2AALDH1A1
SCHEMBL11048463 0.74 MET (0.43) L3MBTL1MAPK1POLBCYP2D6CYP2C9
SCHEMBL11045628 0.72 L3MBTL1 (0.51) L3MBTL1MAPK1POLBCYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4436921-A CARCINOSTATIC ACTIVITY TOYAMA CHEMICAL CO., LTD. (JP) 1984-03-13 US claimed
JP-57140783-A None JP disclosed
US-4477664-A CARCINOSTATIC ACTIVITY, LOW TOXICITY, INTERMEDIATES TOYAMA CHEMICAL CO., LTD. (JP) 1984-10-16 US disclosed
US-4477666-A ANTICARCINO GENIC AGENTS TOYAMA CHEMICAL CO., LTD. (JP) 1984-10-16 US disclosed
US-4460774-A ANTICARCINOGENIC AGENTS TOYAMA CHEMICAL COMPANY, LIMITED (JP) 1984-07-17 US disclosed
US-4459407-A ANTICARCINOGENIC TOYAMA CHEMICAL CO., LTD. (JP) 1984-07-10 US disclosed
US-4448963-A ANTICARCINOGENS TOYAMA CHEMICAL CO., LTD. (JP) 1984-05-15 US disclosed
US-4436921-A CARCINOSTATIC ACTIVITY TOYAMA CHEMICAL CO., LTD. (JP) 1984-03-13 US disclosed
JP-S57140783-A 1-BENZYL-4-(4-(2-PYRIMIDINYLAMINO)BENZYL)-2, 3-DIOXOPIPERAZINE DERIVATIVE AND ITS SALT, THEIR PREPARATION, AND CARCINOSTATIC AGENT CONTAINING THE SAME TOYAMA CHEM CO LTD 1982-08-31 JP disclosed