Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Bromhexine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.71 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.71 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.71 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.31 |
| ▸ | JAK3 known ✓ | P52333 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | AR | P10275 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromhexine SCHEMBL19059 | 0.84 | CYP2D6 (1.00) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL29379593 | 0.84 | CYP2D6 (1.00) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL10704011 | 0.83 | LMNA (1.00) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL99613 | 0.83 | LMNA (1.00) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL18548828 | 0.83 | CYP2D6 (0.97) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL8573766 | 0.80 | CYP2D6 (0.81) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL5968149 | 0.80 | CYP2D6 (0.81) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| SCHEMBL11619080 | 0.78 | CYP2D6 (0.68) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL28142898 | 0.77 | CYP2D6 (0.64) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 | |
| Bromhexine SCHEMBL13723555 | 0.75 | CYP2D6 (0.64) | CYP2D6SLC6A4KCNH2ABCB11ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4438091-A | FOR RESPIRATORY DISORDERS | DR. KARL THOMAE GMBH (DE) | 1984-03-20 | — | — | US | disclosed |