Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Bromhexine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.97 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.97 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.97 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.97 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.97 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.97 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.41 |
| ▸ | NTRK1 known ✓ | P04629 | 1/20 | 0.36 |
| ▸ | RET known ✓ | P07949 | 1/20 | 0.36 |
| ▸ | MET known ✓ | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB known ✓ | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 known ✓ | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA known ✓ | P16234 | 1/20 | 0.36 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.36 |
| ▸ | PRKCQ known ✓ | Q04759 | 1/20 | 0.36 |
| ▸ | ROCK1 known ✓ | Q13464 | 1/20 | 0.36 |
| ▸ | NTRK3 known ✓ | Q16288 | 1/20 | 0.36 |
| ▸ | ALK known ✓ | Q9UM73 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromhexine SCHEMBL10704011 | 1.00 | LMNA (1.00) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Bromhexine SCHEMBL19059 | 0.99 | CYP2D6 (1.00) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Bromhexine SCHEMBL29379593 | 0.99 | CYP2D6 (1.00) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Bromhexine SCHEMBL18548828 | 0.97 | CYP2D6 (0.97) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Bromhexine SCHEMBL8573766 | 0.89 | CYP2D6 (0.81) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Bromhexine SCHEMBL5968149 | 0.89 | CYP2D6 (0.81) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| SCHEMBL13907693 | 0.87 | CYP2D6 (0.79) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Hydrochloric Acid SCHEMBL30080244 | 0.86 | LMNA (0.76) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Hydrochloric Acid SCHEMBL28598338 | 0.86 | CYP3A4 (0.76) | LMNACYP3A4HTTCYP2D6SLC6A4 | |
| Hydrochloric Acid SCHEMBL11879112 | 0.86 | LMNA (0.76) | LMNACYP3A4HTTCYP2D6SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2560 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122056843-A | Bromhexine hydrochloride sustained-release micro tablet and preparation process thereof | 苏州弘森药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122055143-A | Solid compositions containing bromhexine | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| US-12539282-B2 | Bromhexine for the treatment of pain | KERN KAI UWE (DE) | 2026-02-03 | — | — | US | claimed |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2025-08-28 | — | — | US | claimed |
| WO-2025100462-A1 | SOLID COMPOSITION CONTAINING BROMHEXINE | 第一三共ヘルスケア株式会社 | 2025-05-15 | — | — | WO | claimed |
| CN-119857073-A | Bromhexine hydrochloride oral solution | 江苏广承药业有限公司 | 2025-04-22 | — | — | CN | claimed |
| CN-119837825-A | Compound enrofloxacin injection, preparation method and content determination method thereof | 重庆方通动物药业有限公司 | 2025-04-18 | — | — | CN | claimed |
| CN-115980202-B | High performance liquid chromatography detection method for bromhexine hydrochloride crude drug related substances | 山东齐都药业有限公司 | 2025-03-28 | — | — | CN | claimed |
| CN-119606932-A | Bromhexine hydrochloride composition and preparation method thereof | 天津市中升挑战生物科技有限公司 | 2025-03-14 | — | — | CN | claimed |
| CN-119504447-A | Preparation method of bromhexine hydrochloride | 浙江海洲制药股份有限公司 | 2025-02-25 | — | — | CN | claimed |
| CN-1411806-A | Bromhexine hydrochloride injection and its preparation method | NANCHANG YIBO MEDICINE SCIENCE (CN) | 2003-04-23 | — | — | CN | claimed |
| CN-1276246-A | Process for preparing medicines with no or low loxic by-effect on gastrointestinal system | WANG XIAO (CN) | 2000-12-13 | — | — | CN | claimed |
| EP-0583358-B1 | PARTIAL LIQUID BREATHING OF FLUOROCARBONS | ALLIANCE PHARMA (US) | 1998-12-02 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5700410-A | Method of manufacturing wax matrices | NIPPON SHINYAKU CO., LTD. (JP) | 1997-12-23 | — | — | US | claimed |
| CN-1036339-C | Method of preparing N-methylcyclohexylamine as raw material of bromocaproic hydrochloride medicine | JINTAN CITY ASSISTANTS FACTORY (CN) | 1997-11-05 | — | — | CN | claimed |
| EP-0580860-B1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 1997-10-22 | — | — | EP | claimed |
| CN-1092062-A | The production method of the raw material N-methylcyclohexylamine of bromhexine hydrochloride medicine | JINTAN COUNTY ASSISTANTS FACTO (CN) | 1994-09-14 | — | — | CN | claimed |
| EP-0125634-B1 | USE OF A SECRETOLYTICALLY ACTIVE SUBSTANCE FOR THE MANUFACTURE OF A REMEDY AGAINST SNORING AND FOR COMBATING SNORE PHENOMENON | Reichert, Dietrich, Dr. med. (ES) | 1990-09-26 | — | — | EP | claimed |
| EP-0125634-A1 | Use of a secretolytically active substance for the manufacture of a remedy against snoring and for combating snore phenomenon | Reichert, Dietrich, Dr. med. (ES) | 1984-11-21 | — | — | EP | claimed |