Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11048158 | 0.79 | SLC6A4 (0.44) | OPRM1OPRL1SLC6A4NPSR1POLB | |
| SCHEMBL11048173 | 0.76 | SLC6A4 (0.46) | OPRM1OPRL1SLC6A4NPSR1POLB | |
| SCHEMBL2722768 | 0.71 | SMN1; SMN2 (0.59) | OPRM1OPRL1NPSR1HTTSMN1; SMN2 | |
| SCHEMBL20060916 | 0.69 | SMN1; SMN2 (0.65) | OPRM1OPRL1NPSR1HTTMEN1 | |
| SCHEMBL14067363 | 0.68 | SMN1; SMN2 (0.68) | NPSR1HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL145634 | 0.68 | SLC6A3 (0.66) | OPRM1OPRL1SLC6A4CYP2D6 | |
| SCHEMBL14045178 | 0.68 | OPRM1 (0.46) | OPRM1OPRL1HTTKMT2ANPC1 | |
| SCHEMBL4349986 | 0.66 | OPRM1 (1.00) | OPRM1OPRL1 | |
| SCHEMBL12694065 | 0.66 | SLC6A4 (0.47) | OPRM1OPRL1SLC6A4CYP2D6 | |
| SCHEMBL20242106 | 0.65 | SLC6A4 (0.54) | OPRM1SLC6A4NPSR1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4478836-A | 1-Aryl 2-aminomethyl cyclopropane carboxyamide (Z) derivatives and their use as useful drugs in the treatment of disturbances of the central nervous system | PIERRE FABRE S.A. (FR) | 1984-10-23 | — | — | US | disclosed |