Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL460514 | 0.97 | MEN1 (0.59) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Trolamine SCHEMBL10479188 | 0.97 | MEN1 (0.59) | MEN1LMNAKMT2AALDH1A1TSHR | |
| Trolamine SCHEMBL5144735 | 0.92 | MEN1 (0.53) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9580813 | 0.78 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL2313359 | 0.78 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL1270294 | 0.78 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL2188 | 0.78 | — | — | |
| Tromethamine SCHEMBL1524832 | 0.78 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL445853 | 0.78 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4E | |
| Tromethamine SCHEMBL1533756 | 0.78 | MEN1 (0.91) | MEN1LMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4486531-A | SELECTIVE PRECIPITATION | BOEHRINGER MANNHEIM GMBH (DE) | 1984-12-04 | — | — | US | claimed |