Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL460514 | 0.95 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Trolamine SCHEMBL10479188 | 0.95 | MEN1 (0.59) | MEN1LMNAKMT2A | |
| Trolamine SCHEMBL11046229 | 0.92 | MEN1 (0.56) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL565031 | 0.76 | — | — | |
| Trolamine SCHEMBL392210 | 0.76 | MAPT (0.44) | — | |
| Tromethamine SCHEMBL680918 | 0.76 | — | — | |
| Trolamine SCHEMBL3638598 | 0.76 | MAPT (0.44) | — | |
| Trolamine SCHEMBL11132413 | 0.76 | MAPT (0.44) | — | |
| Tromethamine SCHEMBL467992 | 0.76 | MEN1 (0.56) | MEN1LMNAKMT2A | |
| Trolamine SCHEMBL4518758 | 0.76 | MAPT (0.36) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1596869-A4 | NOVEL COCRYSTALLIZATION | S S C I INC (US) | 2007-04-25 | — | — | EP | disclosed |
| EP-1596869-A2 | NOVEL COCRYSTALLIZATION | S.S.C.I., Inc (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004064762-A2 | NOVEL COCRYSTALLIZATION | S.S.C.I. INC. (US) | 2004-08-05 | — | — | WO | disclosed |