Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.67 |
| ▸ | HTR2A | P28223 | 3/20 | 0.67 |
| ▸ | HTR7 | P34969 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7318328 | 0.83 | DRD2 (0.53) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL10895899 | 0.80 | P2RX7 (0.57) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL11046678 | 0.80 | DRD2 (0.47) | DRD2HTR2AHTR7HTR1AHTR6 | |
| SCHEMBL11038162 | 0.77 | ADRA1D (0.68) | LMNASLC6A4ADRA1D | |
| SCHEMBL3036994 | 0.77 | LMNA (0.70) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL11073263 | 0.77 | DRD2 (0.50) | DRD2HTR2AHTR1ALMNADRD3 | |
| SCHEMBL11038195 | 0.76 | LMNA (0.60) | DRD2HTR2AHTR7HTR1ALMNA | |
| SCHEMBL11040157 | 0.76 | LMNA (0.60) | DRD2HTR2AHTR7HTR1ALMNA | |
| Hydrochloric Acid SCHEMBL11037928 | 0.76 | ADRA1D (0.69) | LMNASLC6A4ADRA1D | |
| SCHEMBL9377459 | 0.76 | DRD2 (0.55) | DRD2HTR2AHTR7HTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127167-A2 | 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-12-05 | — | — | EP | claimed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | claimed |
| US-4558056-A | PSYCHOLOGICAL DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4524074-A | TREATMENT OF PSYCHOSES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-06-18 | — | — | US | disclosed |
| EP-0127167-A2 | 3-(4-Piperidinyl)-1,2-benzisothiazoles and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-12-05 | — | — | EP | disclosed |
| US-4458076-A | ANALGESICS, ANTIPSYCHOTICS | HOECHST-ROUSSEL PHARMACEUTICALS (US) | 1984-07-03 | — | — | US | disclosed |