Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.63 |
| ▸ | PLK1 | P53350 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | LPL | P06858 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2088848 | 0.88 | THRA (0.66) | THRBPLK1POLBALDH1A1THRA | |
| SCHEMBL11398616 | 0.84 | THRA (0.73) | THRBALDH1A1THRAKMT2AMAPT | |
| SCHEMBL2464783 | 0.83 | PLK1 (0.60) | THRBPLK1L3MBTL1POLBCTDSP1 | |
| SCHEMBL9861628 | 0.82 | PLK1 (0.64) | THRBPLK1L3MBTL1POLBCTDSP1 | |
| SCHEMBL4211721 | 0.82 | ALDH1A1 (0.64) | THRBPLK1POLBALDH1A1GAA | |
| SCHEMBL11645482 | 0.82 | THRB (0.75) | THRBPLK1L3MBTL1POLBCTDSP1 | |
| Hydrochloric Acid SCHEMBL27539972 | 0.81 | PLK1 (0.58) | THRBPLK1L3MBTL1POLBCTDSP1 | |
| SCHEMBL44017 | 0.80 | RARB (0.69) | THRBPLK1L3MBTL1POLBCTDSP1 | |
| SCHEMBL1483217 | 0.80 | KMT2A (0.64) | THRBPLK1L3MBTL1POLBCTDSP1 | |
| SCHEMBL4396484 | 0.80 | PLK1 (0.62) | THRBPLK1L3MBTL1POLBCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4438277-A | Hydronaphthalene derivatives | SANKYO COMPANY, LIMITED (JP) | 1984-03-20 | — | — | US | disclosed |
| US-4361515-A | Antihyperlipemic dihydro-ML-236B derivatives, their preparation and use | SANKYO COMPANY, LIMITED (JP) | 1982-11-30 | — | — | US | disclosed |
| US-3971825-A | (5,6) (10,11) BIS-METHYLENE, BRONCHODILATORS | SANKYO COMPANY LIMITED (JA) | 1976-07-27 | — | — | US | disclosed |