Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.40 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11048023 | 1.00 | HRH1 (0.41) | HRH1HRH2CHRM4CHRM3LMNA | |
| Fumaric Acid SCHEMBL11051336 | 0.87 | HRH2 (0.44) | HRH1HRH2LMNASMN1; SMN2MEN1 | |
| SCHEMBL11048663 | 0.87 | HRH3 (0.45) | HRH1CHRM4CHRM3SMN1; SMN2HRH3 | |
| Fumaric Acid SCHEMBL9682573 | 0.84 | CHRM3 (0.49) | HRH1HRH2CHRM4CHRM3LMNA | |
| Maleic Acid SCHEMBL9682566 | 0.84 | CHRM3 (0.49) | HRH1HRH2CHRM4CHRM3LMNA | |
| Fumaric Acid SCHEMBL11045460 | 0.78 | SLC6A2 (0.46) | HRH1HRH2CHRM4CHRM3LMNA | |
| Fumaric Acid SCHEMBL11045472 | 0.78 | SLC6A2 (0.46) | HRH1HRH2CHRM4CHRM3LMNA | |
| SCHEMBL11048973 | 0.77 | HRH3 (0.39) | CHRM4CHRM3MAPK1KDM4EHRH3 | |
| Fumaric Acid SCHEMBL10629588 | 0.71 | ALDH1A1 (0.32) | HRH1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL11046292 | 0.70 | ALDH1A1 (0.40) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451473-A | 3,7-Diazabicyclo [3.3.1] nonanes having anti-arrhythmic activity | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1984-05-29 | — | — | US | disclosed |