Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.49 |
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.46 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.45 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9682566 | 1.00 | CHRM3 (0.49) | CHRM3CHRM4HRH1SLC6A2SLC6A3 | |
| SCHEMBL9683676 | 0.86 | SLC6A2 (0.56) | CHRM3CHRM4HRH1SLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL11048014 | 0.84 | HRH1 (0.41) | CHRM3CHRM4HRH1HRH2MEN1 | |
| Fumaric Acid SCHEMBL11048023 | 0.84 | HRH1 (0.41) | CHRM3CHRM4HRH1HRH2MEN1 | |
| Sulfuric Acid SCHEMBL9596786 | 0.83 | CHRM3 (0.47) | CHRM3CHRM4SLC6A2SLC6A3USP30 | |
| SCHEMBL16707767 | 0.79 | SLC6A2 (0.53) | CHRM3CHRM4HRH1SLC6A2SLC6A3 | |
| SCHEMBL6123500 | 0.75 | SCD (0.51) | CHRM3SLC6A2SLC6A3USP30CHRM2 | |
| SCHEMBL714763 | 0.74 | SMN1; SMN2 (0.59) | CHRM3CHRM4HRH1SLC6A2SLC6A3 | |
| SCHEMBL10262302 | 0.74 | SMN1; SMN2 (0.59) | CHRM3CHRM4HRH1SLC6A2SLC6A3 | |
| SCHEMBL10261345 | 0.74 | SMN1; SMN2 (0.59) | CHRM3CHRM4HRH1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5130309-A | Cardiovascular disorders | A. H. ROBINS COMPANY, INCORPORATED (US) | 1992-07-14 | — | — | US | disclosed |