Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050707 | 0.87 | KMT2A (0.52) | MAPTKMT2AMEN1NPC1MAPK1 | |
| SCHEMBL11254196 | 0.87 | MAPT (0.55) | MAPTKMT2AMEN1NPC1MAPK1 | |
| SCHEMBL11054953 | 0.86 | TBXA2R (0.44) | MAPTKMT2AMEN1ALDH1A1CYP2C9 | |
| SCHEMBL11054990 | 0.86 | TBXA2R (0.47) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11052550 | 0.86 | GAA (0.51) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL11053862 | 0.84 | ALDH1A1 (0.48) | MAPTKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL11049847 | 0.84 | PKM (0.60) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL11052114 | 0.82 | PDK1 (0.50) | MAPTKMT2AMEN1NPC1MAPK1 | |
| SCHEMBL11055535 | 0.82 | APP (0.54) | MAPTKMT2AMEN1NPC1MAPK1 | |
| SCHEMBL11052904 | 0.81 | HTT (0.47) | KMT2AMEN1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |