Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11254196 | 0.87 | MAPT (0.55) | TBXA2RALDH1A1L3MBTL1HTTLMNA | |
| SCHEMBL11050707 | 0.87 | KMT2A (0.52) | TBXA2RALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL11054953 | 0.86 | TBXA2R (0.44) | TBXA2RALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL11052550 | 0.86 | GAA (0.51) | TBXA2RALDH1A1GAALMNAMEN1 | |
| SCHEMBL11052090 | 0.86 | MAPT (0.54) | TBXA2RALDH1A1HTTLMNAMEN1 | |
| SCHEMBL11049847 | 0.84 | PKM (0.60) | ALDH1A1GAAL3MBTL1HTTLMNA | |
| SCHEMBL11053862 | 0.84 | ALDH1A1 (0.48) | TBXA2RALDH1A1GAAL3MBTL1HTT | |
| SCHEMBL11252215 | 0.83 | RORC (0.46) | ALDH1A1HTTPOLBKMT2ARORC | |
| SCHEMBL11052097 | 0.82 | PDK1 (0.39) | ALDH1A1HTTLMNAMAPT | |
| SCHEMBL11250897 | 0.81 | PKM (0.48) | TBXA2RHTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4326074-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |