Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 8/20 | 0.55 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.55 |
| ▸ | FAP | Q12884 | 5/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.55 |
| ▸ | PREP | P48147 | 3/20 | 0.55 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | ACE | P12821 | 6/20 | 0.45 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PEPD | P12955 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14235325 | 0.83 | DPP4 (0.58) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL10056861 | 0.83 | DPP4 (0.58) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL593691 | 0.83 | ACE (0.64) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL7994236 | 0.83 | DPP4 (0.58) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL2031886 | 0.83 | DPP4 (0.58) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL2115246 | 0.83 | ACE (0.64) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL2031883 | 0.83 | DPP4 (0.58) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL7271951 | 0.83 | ACE (0.64) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL22673059 | 0.83 | DPP4 (0.58) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL8316371 | 0.83 | ACE (0.64) | DPP4DPP7FAPDPP8PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4442030-A | ARALKYLATION WITH BENZOYLACRYLIC ACID, HYDROGENATION, ESTERIFICATION | MERCK & CO., INC. (US) | 1984-04-10 | — | — | US | disclosed |