Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15821851 | 0.88 | P2RX7 (0.50) | AURKATPX2P2RX7KEAP1CA1 | |
| SCHEMBL27185264 | 0.78 | P2RX7 (0.48) | AURKATPX2P2RX7KDM4EALDH1A1 | |
| SCHEMBL15797458 | 0.78 | P2RX7 (0.55) | AURKATPX2P2RX7KEAP1CSNK2A2 | |
| SCHEMBL15797491 | 0.75 | P2RX7 (0.55) | AURKATPX2P2RX7KEAP1 | |
| SCHEMBL15824103 | 0.75 | P2RX7 (0.54) | AURKATPX2P2RX7KEAP1CSNK2A2 | |
| SCHEMBL3914056 | 0.75 | THRB (0.56) | CA1CA2THRBCDK2KDM4E | |
| SCHEMBL5187984 | 0.74 | KEAP1 (0.49) | AURKATPX2KEAP1CSNK2A2CSNK2B | |
| SCHEMBL29764483 | 0.74 | KEAP1 (0.49) | AURKATPX2KEAP1CSNK2A2CSNK2B | |
| SCHEMBL13983382 | 0.73 | AURKA (0.49) | AURKATPX2KEAP1CA1CA2 | |
| SCHEMBL15797467 | 0.73 | P2RX7 (0.57) | AURKATPX2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4489165-A | CONJUGATE OF LIGAND, SPACER, AND CHROMOGEN | BECTON DICKINSON AND COMPANY (US) | 1984-12-18 | — | — | US | disclosed |
| EP-0115332-A2 | Chromogenic tracers for use in an assay | Becton Dickinson and Company (US) | 1984-08-08 | — | — | EP | disclosed |
| EP-0018731-B1 | MACROMOLECULAR GLYCOSIDASE SUBSTRATES | SYVA COMPANY (US) | 1983-01-12 | — | — | EP | disclosed |
| US-4268663-A | COMPRISING A POLYSACCHARIDE SUPPORT, AN AMINE-CONTAINING SPACER ARM, AND A CHROMOGEN ENZYMATICALLY LABILE-LINKED TO A MONOSACCHARIDE; IMMUNOASSAY | SYVA COMPANY (US) | 1981-05-19 | — | — | US | disclosed |
| EP-0018731-A1 | Macromolecular glycosidase substrates | SYVA COMPANY (US) | 1980-11-12 | — | — | EP | disclosed |