Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | F3 | P13726 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283125 | 0.83 | BRD4 (0.46) | CCR8ALDH1A1 | |
| SCHEMBL988532 | 0.79 | KEAP1 (0.56) | AURKATPX2F7F3DYRK1A | |
| SCHEMBL11699295 | 0.74 | CCR8 (0.60) | AURKATPX2CCR8KMT2AALDH1A1 | |
| SCHEMBL7291123 | 0.74 | CCR8 (0.50) | AURKATPX2CCR8KMT2AALDH1A1 | |
| SCHEMBL11057997 | 0.73 | AURKA (0.46) | AURKATPX2F7F3KMT2A | |
| SCHEMBL5187984 | 0.70 | KEAP1 (0.49) | AURKATPX2F7F3KMT2A | |
| SCHEMBL29764483 | 0.70 | KEAP1 (0.49) | AURKATPX2F7F3KMT2A | |
| SCHEMBL27185264 | 0.69 | P2RX7 (0.48) | AURKATPX2ALDH1A1KDM4E | |
| SCHEMBL6537755 | 0.69 | CHUK (0.48) | CCR8KMT2AALDH1A1 | |
| SCHEMBL11660386 | 0.69 | KEAP1 (0.55) | AURKATPX2CCR8KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157273-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |