Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058424 | 0.90 | HCAR1 (0.37) | TDP1HCAR1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11050218 | 0.90 | HCAR1 (0.37) | HCAR1POLBMAPK14CHRNA7MAPK11 | |
| SCHEMBL11055569 | 0.88 | CHRNA7 (0.43) | TDP1HCAR1CHRNA7 | |
| SCHEMBL11055471 | 0.85 | HCAR1 (0.38) | HCAR1CHRNA7SMN1; SMN2ALOX15 | |
| SCHEMBL11055617 | 0.81 | FGFR1 (0.39) | HCAR1MAPK14CHRNA7MAPK11 | |
| SCHEMBL11347343 | 0.81 | ANPEP (0.36) | HCAR1LMNAALDH1A1 | |
| SCHEMBL11053513 | 0.80 | MAPK14 (0.39) | MAPK14CHRNA7ALDH1A1 | |
| SCHEMBL11056331 | 0.79 | MAT2A (0.41) | HCAR1LMNAALDH1A1TSHR | |
| SCHEMBL11359839 | 0.79 | SLC29A1 (0.36) | HCAR1LMNAALDH1A1HTT | |
| SCHEMBL11058764 | 0.79 | FGFR1 (0.41) | HCAR1MAPK14CHRNA7MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |