Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11060167 | 0.88 | TDP1 (0.38) | CHRNA7TDP1HCAR1 | |
| SCHEMBL11055471 | 0.87 | HCAR1 (0.38) | CHRNA7HCAR1 | |
| SCHEMBL11059289 | 0.85 | HCAR1 (0.36) | CHRNA7HCAR1 | |
| SCHEMBL11056383 | 0.83 | HCAR1 (0.40) | HCAR1 | |
| SCHEMBL11060209 | 0.82 | HCAR1 (0.41) | HCAR1 | |
| SCHEMBL11058424 | 0.81 | HCAR1 (0.37) | TDP1HCAR1 | |
| SCHEMBL11059306 | 0.80 | CHRNA7 (0.45) | CHRNA7LCK | |
| SCHEMBL11054591 | 0.79 | CHRNA7 (0.46) | CHRNA7HCAR1 | |
| SCHEMBL11059656 | 0.79 | HCAR1 (0.43) | CHRNA7HCAR1 | |
| SCHEMBL11058286 | 0.79 | EGFR (0.45) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |