Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 10/20 | 0.38 |
| ▸ | MAOB | P27338 | 10/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11070160 | 0.84 | MAOB (0.57) | MAOAMAOBDRD2 | |
| Iodide SCHEMBL11071817 | 0.82 | SLC18A3 (0.46) | SLC18A3MAOAMAOBCYP19A1CYP11B1 | |
| Iodide SCHEMBL11067095 | 0.82 | MAOB (0.57) | MAOAMAOBDRD2 | |
| Iodide SCHEMBL11068796 | 0.79 | SLC18A3 (0.45) | SLC18A3DRD2 | |
| Iodide SCHEMBL11071122 | 0.77 | MAOB (0.53) | MAOAMAOBDRD2 | |
| Hydrochloric Acid SCHEMBL11065317 | 0.76 | MAOB (0.51) | MAOAMAOBDRD2 | |
| Iodide SCHEMBL11063822 | 0.76 | MAOB (0.48) | MAOAMAOBDRD2 | |
| Hydrochloric Acid SCHEMBL11076015 | 0.74 | MAOB (0.48) | MAOAMAOBDRD2 | |
| Hydrochloric Acid SCHEMBL11066425 | 0.73 | ADRB2 (0.39) | SLC18A3DRD2 | |
| Hydrochloric Acid SCHEMBL11063001 | 0.72 | MAOB (0.65) | MAOAMAOBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482560-A | Carbostyril derivatives, and antihistaminic agents containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-11-13 | — | — | US | disclosed |